Kisspeptin-10 (KISS1) — Research Use Only

Kisspeptin-10 is a synthetic peptide fragment of the endogenous kisspeptin signaling family, widely used in research settings to study KISS1R (GPR54) receptor activity and downstream regulation within the hypothalamic–pituitary–gonadal (HPG) axis. In controlled laboratory models, Kisspeptin-10 is employed as a tool peptide to explore GnRH-associated signaling, endocrine feedback mechanisms, and biomarker changes related to reproductive hormone regulation (model-dependent).

Research Applications & Study Interest

Kisspeptin-10 is commonly utilized in in vitro and preclinical research contexts to investigate:

• KISS1R (GPR54) receptor signaling: receptor activation dynamics and pathway mapping

• HPG axis pathway modeling: exploring upstream regulation patterns that influence GnRH-associated signaling

• Gonadotropin-related biomarkers: experimental readouts tied to LH/FSH signaling cascades (model-dependent)

• Neuroendocrine research models: studying hypothalamic signaling networks and endocrine feedback loops

• Reproductive biology assays: gene/protein expression changes in endocrine and reproductive pathway models

Mechanism of Research Interest (High-Level)

Kisspeptin signaling is studied for its role in the regulation of GnRH neuron activity and downstream endocrine pathways. Kisspeptin-10 is used as a research tool to evaluate:

• KISS1R-mediated signaling cascades

• Neuroendocrine pathway interactions

• Hormone regulation biomarkers relevant to HPG axis models

Observed outcomes depend on experimental design, model selection, assay type, and controls.

Typical Research Formats

• Commonly supplied as a lyophilized powder for controlled laboratory preparation

• Researchers may confirm identity/purity using HPLC/LC-MS depending on protocol requirements